It was Wednesday 16 February 2011, and Goldman was at a hotel in Hamburg, Germany, talking with some of his fellow bioinformaticists about how they could afford to store the reams of genome sequences and other data the world was throwing at them. He remembers the scientists getting so frustrated by the expense and limitations of conventional computing technology that they started kidding about sci-fi alternatives. “We thought, ‘What’s to stop us using DNA to store information?’”
Then the laughter stopped. “It was a lightbulb moment,” says Goldman, a group leader at the European Bioinformatics Institute (EBI) in Hinxton, UK. True, DNA storage would be pathetically slow compared with the microsecond timescales for reading or writing bits in a silicon memory chip. It would take hours to encode data by synthesizing DNA strings with a specific pattern of bases, and still more hours to recover that information using a sequencing machine. But with DNA, a whole human genome fits into a cell that is invisible to the naked eye. For sheer density of information storage, DNA could be orders of magnitude beyond silicon — perfect for long-term archiving.
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
The engineered ribosome may enable the production of new drugs and next-generation biomaterials and lead to a better understanding of how ribosomes function.
The artificial ribosome, called Ribo-T, was created in the laboratories of Alexander Mankin, director of the UIC College of Pharmacy’s Center for Biomolecular Sciences, and Northwestern’s Michael Jewett, assistant professor of chemical and biological engineering.
Cédric Orelle, Erik D. Carlson, Teresa Szal, Tanja Florin, Michael C. Jewett, Alexander S. Mankin. Protein synthesis by ribosomes with tethered subunits. Nature, 2015; DOI: 10.1038/nature14862
The artificial ribosome, called Ribo-T, was created in the laboratories of Alexander Mankin, director of the UIC College of Pharmacy’s Center for Biomolecular Sciences, and Northwestern’s Michael Jewett.