Design first artificial ribosome


science-junkie | currentsinbiology

Researchers design first artificial ribosome

Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.

The engineered ribosome may enable the production of new drugs and next-generation biomaterials and lead to a better understanding of how ribosomes function.

The artificial ribosome, called Ribo-T, was created in the laboratories of Alexander Mankin, director of the UIC College of Pharmacy’s Center for Biomolecular Sciences, and Northwestern’s Michael Jewett, assistant professor of chemical and biological engineering.

Cédric Orelle, Erik D. Carlson, Teresa Szal, Tanja Florin, Michael C. Jewett, Alexander S. Mankin. Protein synthesis by ribosomes with tethered subunits. Nature, 2015; DOI: 10.1038/nature14862

The artificial ribosome, called Ribo-T, was created in the laboratories of Alexander Mankin, director of the UIC College of Pharmacy’s Center for Biomolecular Sciences, and Northwestern’s Michael Jewett.

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